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Ernst Kubista Selected Research

Therapeutics

7/2014High-level ERBB2 gene amplification is associated with a particularly short time-to-metastasis, but results in a high rate of complete response once trastuzumab-based therapy is offered in the metastatic setting.
12/2011Effects of tibolone on climacteric symptoms and quality of life in breast cancer patients--data from LIBERATE trial.
6/2011Differential expression pattern of estrogen receptors, aromatase, and sulfotransferase in breast cancer tissue and corresponding lymph node metastases.
5/2010Administration of betaHCG leads to dose-dependent changes of gene expression signature of endometriotic stromal cells.
9/2009Low p27 expression predicts early relapse and death in postmenopausal hormone receptor-positive breast cancer patients receiving adjuvant tamoxifen therapy.
9/2008Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy.
12/2007Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a.
3/2006Her-2/neu and EGFR tyrosine kinase activation predict the efficacy of trastuzumab-based therapy in patients with metastatic breast cancer.
3/2006Proteomic analysis in human breast cancer: identification of a characteristic protein expression profile of malignant breast epithelium.
1/2006Serum EGFR levels and efficacy of trastuzumab-based therapy in patients with metastatic breast cancer.
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Ernst Kubista Research Topics

Disease

44Breast Neoplasms (Breast Cancer)
11/2014 - 03/2002
33Neoplasms (Cancer)
11/2014 - 03/2002
8Colorectal Neoplasms (Colorectal Cancer)
09/2009 - 12/2002
5Neoplasm Metastasis (Metastasis)
07/2014 - 03/2002
5Carcinogenesis
02/2009 - 03/2003
4Carcinoma (Carcinomatosis)
07/2007 - 03/2003
3Endometriosis
05/2010 - 10/2005
2Lymphatic Metastasis
06/2011 - 08/2004
2Ductal Carcinoma
03/2009 - 03/2003
2Disease Progression
03/2006 - 01/2006
1Pelvic Pain
05/2010
1Inflammation (Inflammations)
05/2010
1Noninfiltrating Intraductal Carcinoma (DCIS)
04/2010
1Pathologic Complete Response
05/2007
1Phyllodes Tumor (Cystosarcoma Phylloides)
12/2006
1Leukemia
02/2006
1Ovarian Neoplasms (Ovarian Cancer)
01/2006
1Colonic Neoplasms (Colon Cancer)
12/2004
1Mastodynia
12/2004
1Breast Diseases (Breast Disease)
06/2004
1Kidney Neoplasms (Kidney Cancer)
02/2004
1Renal Cell Carcinoma (Grawitz Tumor)
02/2004
1Adenocarcinoma of Lung
02/2004
1Squamous Cell Neoplasms (Squamous Cell Cancer)
02/2004
1Necrosis
09/2003

Drug/Important Bio-Agent (IBA)

17Proteins (Proteins, Gene)FDA Link
05/2010 - 03/2002
10Hormones (Hormone)IBA
06/2011 - 04/2002
7Estrogen ReceptorsIBA
11/2014 - 03/2003
7TamoxifenFDA LinkGeneric
09/2009 - 12/2002
6Biological ProductsIBA
05/2010 - 08/2004
5Complementary DNA (cDNA)IBA
05/2010 - 02/2004
4Trastuzumab (Herceptin)FDA Link
07/2014 - 08/2005
4tiboloneIBA
01/2012 - 07/2007
4CytokinesIBA
03/2009 - 04/2002
4Goserelin (Zoladex)FDA Link
09/2008 - 12/2002
4Messenger RNA (mRNA)IBA
07/2008 - 03/2002
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
08/2007 - 12/2004
3Estrogens (Estrogen)FDA Link
11/2014 - 12/2006
3Steroid Receptors (Steroid Receptor)IBA
11/2014 - 03/2003
3ParaffinIBA
06/2011 - 08/2004
3Estrogen Receptor alphaIBA
10/2005 - 03/2003
2SteroidsIBA
12/2011 - 12/2002
2EnzymesIBA
06/2011 - 03/2002
2Aromatase (CYP19)IBA
06/2011 - 12/2006
2SulfotransferasesIBA
06/2011 - 12/2006
2Letrozole (Femara)FDA LinkGeneric
06/2009 - 12/2007
2ErbB Receptors (EGF Receptor)IBA
03/2009 - 12/2004
2LH Receptors (LH Receptor)IBA
02/2009 - 07/2008
2Anastrozole (Arimidex)FDA LinkGeneric
09/2008 - 12/2007
2Transcription Factors (Transcription Factor)IBA
07/2008 - 06/2002
2Aminoglutethimide (Cytadren)FDA Link
12/2007 - 03/2003
2Docetaxel (Taxotere)FDA Link
05/2007 - 02/2003
2Tyrosine (L-Tyrosine)FDA Link
02/2006 - 12/2004
2Estrogen Receptor betaIBA
10/2005 - 03/2003
2AntibodiesIBA
08/2004 - 03/2003
2Insulin-Like PeptidesIBA
06/2004 - 02/2003
2Fluorouracil (Carac)FDA LinkGeneric
10/2003 - 12/2002
2Methotrexate (Mexate)FDA LinkGeneric
10/2003 - 12/2002
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
10/2003 - 12/2002
1EstetrolIBA
11/2014
1Adiponectin ReceptorsIBA
04/2010
1Carrier Proteins (Binding Protein)IBA
04/2010
1AdiponectinIBA
04/2010
1Biomarkers (Surrogate Marker)IBA
09/2009
1EverolimusFDA Link
06/2009
1ixabepilone (BMS 247550)FDA Link
02/2009
1Zoledronic Acid (Zometa)FDA Link
09/2008
1Aromatase InhibitorsIBA
12/2007
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
05/2007
1Epirubicin (Ellence)FDA LinkGeneric
05/2007
1Antineoplastic Agents (Antineoplastics)IBA
03/2006
1Imatinib Mesylate (Gleevec)FDA Link
02/2006
1Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA
10/2005
1multidrug resistance-associated protein 1IBA
02/2005
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
02/2005
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
12/2004
1Epidermal Growth Factor (EGF)IBA
12/2004
1Phosphotransferases (Kinase)IBA
12/2004
1Somatomedin Receptors (Somatomedin Receptor)IBA
12/2004
1salicylhydroxamic acid (SHAM)IBA
12/2004
1Monoclonal AntibodiesIBA
08/2004
1Insulin-Like Growth Factor II (Somatomedin A)IBA
06/2004
1MitogensIBA
06/2004
1Insulin-Like Growth Factor I (IGF-1)IBA
06/2004
1S100 Proteins (S 100 Protein)IBA
02/2004
1Progesterone Receptors (Progesterone Receptor)IBA
10/2003
1Interleukin-1 (Interleukin 1)IBA
10/2003
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
10/2003
1Interleukin-1alpha (Interleukin 1 alpha)IBA
10/2003
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
09/2003
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2003
1DNA (Deoxyribonucleic Acid)IBA
07/2003

Therapy/Procedure

17Therapeutics
07/2014 - 04/2002
3Neoadjuvant Therapy
06/2009 - 05/2007
3Drug Therapy (Chemotherapy)
02/2005 - 12/2002
1Hormone Replacement Therapy (Therapy, Hormone Replacement)
01/2012
1Off-Label Use
12/2011
1Hormonal Contraception
01/2009
1Aftercare (After-Treatment)
07/2007
1Segmental Mastectomy (Lumpectomy)
05/2007